Molecular cellSchizosaccharomycesSchizosaccharomyces pombe ProteinsRNA Polymerase IIDNA ReplicationR-Loop Structures
Dcr1 senses R-loops for RNAPII termination at sites of replication stress and repair pathway choice.
Zihao Wang, Yizheng Zhang, Ting Guo, Ming He, Yingying Xu, Sonali Bhattacharjee, Robert A Martienssen, Jie Ren
Published: 202510.1016/j.molcel.2025.10.004
Abstract
Stalled RNA polymerase II (RNAPII) threatens genome integrity, yet how cells resolve transcription blocks at difficult-to-terminate sites is unclear. Leveraging the compact genome of fission yeast and termination defects associated with the non-canon…
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