Molecular cellUbiquitinationHumansUbiquitin-Protein LigasesLysineUbiquitin
Split-site ubiquitination gives ZNFX1 new power in RNA defense.
Stacy M Horner
Published: 202510.1016/j.molcel.2025.09.022
Abstract
Recent work by Grabarczyk et al.1 uncovers the molecular mechanism by which ZNFX1, an interferon-stimulated gene, employs a novel split-site E3 ligase domain structure to ubiquitinate both protein lysine residues and RNA 2' hydroxyls. This activity e…
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