Molecular cellPoly (ADP-Ribose) Polymerase-1DNA ReplicationHumansPoly(ADP-ribose) Polymerase InhibitorsDNA
PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed.
Jonas D Elsborg, Sebastian H N Munk, Alba Adelantado-Rubio, Ramóna Pék, Zita Fábian, Victor Imburchia, Siham Zentout, Ivo A Hendriks, Sara C Buch-Larsen, Rebecca Smith, Jiri Bartek, Julien P Duxin, Sébastien Huet, Apolinar Maya-Mendoza, Michael L Nielsen
Published: 202510.1016/j.molcel.2025.09.006
Abstract
Poly(ADP-ribose) polymerase (PARP) inhibitors have proven their efficacy for treating tumors defective in homologous recombination via synthetic lethality. In response to DNA breaks, PARP1 is the primary ADP-ribosylation writer, modifying itself (aut…
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