Microbial pathogenesisVibrio parahaemolyticusHemolysin ProteinsBacterial ProteinsHemolysisDrug Evaluation
Structure-based screening and in vitro validation of potentially druggable molecules against Vibrio parahaemolyticus thermostable direct hemolysin (TDH) protein.
Prasenjit Paria, Sandeep Yadav, Prakash Biswas, Nikhila Pathapati, Amirul Islam Mallick
Published: 202610.1016/j.micpath.2025.108140
Abstract
Thermostable Direct Hemolysin (TDH) protein is a key virulence factor of Vibrio parahaemolyticus, responsible for hemolysis, cardiotoxicity, and enterotoxicity. TDH is naturally synthesized as a soluble monomer and subsequently oligomerizes into a te…
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