Microbial pathogenesisHumansApoptosisHEK293 CellsBacterial Outer Membrane ProteinsCytokines
Mechanism of Brucella pathogenesis mediated by outer membrane protein Omp19: Synergistic activation of cytokine storm and dual apoptotic pathways.
Xinhui Wei, Xinyuan Xu, Shuai Zhang, Hua Guo, Yubo Zhao, Yitong Cui, Bingrong Wu, Saisai Zhao, Guoyang Liang, Zhen Chen, Guocheng Liu, Yi Tang, Youxiang Diao
Published: 202610.1016/j.micpath.2025.108125
Abstract
Upon host cell invasion, Brucella exhibits dual regulatory effects on apoptosis, demonstrating both pro-apoptotic and anti-apoptotic capabilities. Existing studies have confirmed that Omp31 and Omp25 possess apoptosis-inhibitory properties, while Omp…
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