Microbes and infection
Caffeic acid reduces Toxoplasma gondii proliferation in human extravillous trophoblast cells (HTR8/SVneo) through induction of pro-inflammatory cytokines and a death process suggestive of apoptosis.
Yasmin Munhoz Dos Santos-Destro, Angélica Paulina Nunes, Raquel Arruda da Silva Sanfelice, Virgínia Marcia Concato, Taylon Felipe Silva, Mariana Barbosa Detoni, Danielle Lazarin-Bidoia, Sara Mayumi Suzuki, Guilherme de Souza, João Luís Garcia, Ivete Conchon-Costa, Wander Rogério Pavanelli, Bellisa de Freitas Barbosa, Eloisa Amália Vieira Ferro, Idessania Nazareth Costa
Published: 202510.1016/j.micinf.2025.105584
Abstract
BACKGROUND: Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is a public health problem, especially in congenital infections. Current treatments, with spiramycin or pyrimethamine and sulfadiazine, are highly toxic, prompting the search for e…
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