Metabolism: clinical and experimental
HMGCS2 desuccinylation modulates acetoacetate to drive tubule-macrophage inflammatory crosstalk in diabetic kidney disease.
Ziyue Lin, Dan Lv, He Zha, Handeng Liu, Rui Peng, Jiakun Yang, Wuchao Li, Xiaohui Liao, Yan Sun, Zheng Zhang
Published: 202610.1016/j.metabol.2026.156510
Abstract
Mitochondrial dysfunction in renal tubular epithelial cells (TECs) is a hallmark of diabetic kidney disease (DKD), accompanied by macrophage infiltration, yet how metabolic perturbations in TECs-macrophage driven inflammation remains unclear. Here, w…
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