Metabolism: clinical and experimentalAnimalsSemaphorinsMicePyroptosisNLR Family
The SEMA7AN559Y mutation facilitates the development of metabolic dysfunction-associated steatotic liver disease by inducing ROS/NLRP3-mediated hepatic cell pyroptosis.
Xiaoxun Zhang, Jiaxin Lei, Nan Zhao, Zhixian Zhu, Jingjing Ding, Qiong Pan, Wen-Yue Liu, Xiao-Zhi Jin, Li-You Lian, Ming-Hua Zheng, Jin Chai
Published: 202610.1016/j.metabol.2025.156483
Abstract
BACKGROUND AND AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver condition that can result in significant liver damage. This study aimed to evaluate the effects of the SEMA7AN559Y mutation on MASLD progr…
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