Metabolism: clinical and experimentalCD8-Positive T-LymphocytesObesityAnimalsAdipose TissueIron
Obesity rewires CD8+ T cell iron metabolism in adipose tissue to fuel metabolic inflammation.
Jinfen Dai, Zixuan Zeng, Lishuan Wang, Wei Yuan, Karina Cunha E Rocha, Junho Park, Garam An, Ke Wang, Jisoo Song, Qian Xiang, Ying Duan, Chengjia Qian, Varsha Beldona, Whasun Lim, Enfu Hui
Published: 202610.1016/j.metabol.2025.156438
Abstract
Sufficient nutrient supply is important for the maintenance of non-lymphoid tissue resident CD8+ T cell homeostasis, but the role of labile iron remains unclear. Here, we find adipose tissue CD8+ T cells exhibit elevated labile iron and mitochondrial…
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