Metabolism: clinical and experimentalAnimalsParaventricular Hypothalamic NucleusEnergy MetabolismThyrotropin-Releasing HormoneMice
BCAA catabolism in TRH neurons of paraventricular nucleus regulates energy expenditure.
Xing Ming, Jialin Tan, Miaomiao Yuan, Xiaoqin Ma, Feiye Zhou, Shushu Wang, Qianqian Lyu, Wenzhi Xue, Tingting Bo, Yunxia Liu, Xuejiao Zhang, Fuhua Yan, Jie Hong, Jie Zheng, Guang Ning
Published: 202610.1016/j.metabol.2025.156435
Abstract
The role of hypothalamic branched-chain amino acid (BCAA) catabolism in the maintenance of energy homeostasis remains elusive. By using Mendelian randomization, we found that genetically predicted branched-chain keto acid dehydrogenase E1α subunit (B…
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