Metabolism: clinical and experimentalAnimalsFerroptosisMiceAutophagyLysosomes
Sphk2 suppresses ferroptosis in ischemic hearts by promoting HSP90AA1-mediated TFEB nuclear translocation, lysosome biogenesis and lysosome-autophagy pathway-dependent lipid-ROS clearance.
Ting Gong, Danru Wang, Yawei Jin, Liming Chen, Nan Qiu, Wenyan Qiu, Na Zheng, Yang Lv, Suling Ding, Jie Yuan, Jian Wu, Ling Lin, Chunjie Yang, Miyesaier Abudureyimu, Xiang Wang
Published: 202610.1016/j.metabol.2025.156428
Abstract
BACKGROUND: Lipid peroxidation and iron overload-mediated cardiac ferroptosis play a critical role in myocardial ischemic injury and remodeling. Sphingosine kinase 2 (Sphk2) is implicated in lipid metabolism and cell survival, yet its role in myocard…
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