Metabolism: clinical and experimentalHumansInsulin SecretionLysinegamma-Aminobutyric AcidDiabetes Mellitus
Lysine potentiates insulin secretion via AASS-dependent catabolism and regulation of GABA content and signaling.
Felipe Muñoz, Qian Gao, Matthias Mattanovich, Kajetan Trost, Ondřej Hodek, Andreas Lindqvist, Nils Wierup, Malin Fex, Thomas Moritz, Hindrik Mulder, Luis Rodrigo Cataldo
Published: 202610.1016/j.metabol.2025.156423
Abstract
Lysine is an essential amino acid with insulinotropic effects in humans. In vitro, it enhances glucose-stimulated insulin secretion (GSIS) in β-cell lines and rodent islets. While lysine is thought to act via membrane depolarization similar to argini…
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