Metabolism: clinical and experimentalAnimalsInsulin-Secreting CellsSerine-Arginine Splicing FactorsMiceCell Proliferation
SRSF1 is essential for pancreatic β-cell proliferation and the maintenance of glucose homeostasis in mice.
Xue You, Qian Peng, Wenju Qian, Zhiqin Xie, Yijun Lin, Yikuo Gai, Jingran Ye, Ying Feng
Published: 202610.1016/j.metabol.2025.156421
Abstract
BACKGROUND: β-Cell proliferation is vital for adapting to metabolic stress. Failure to expand β-cell mass during insulin resistance and aging contributes to dysfunction and diabetes. Understanding the mechanisms behind β-cell proliferation issues and…
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