Metabolism: clinical and experimentalAnimalsForkhead Box Protein O1MiceMethyltransferasesLipid Metabolism
METTL1-mediated m7G methylation of FoxO1 regulates lipid metabolism in metabolic dysfunction-associated fatty liver disease.
Jiang Du, Yujie Li, Xinxing Zhu, Jingwen Gao, Yuxuan Zhang, Chiheng Wang, Di Han, Liang Qiao, Beilin Kou, Rui Guo, Hongen Zhang, Juntang Lin
Published: 202610.1016/j.metabol.2025.156420
Abstract
Metabolic dysfunction-associated fatty liver disease (MASLD) is characterized by the accumulation and degeneration of lipids in hepatocytes, presenting a complex pathogenesis that complicates drug development. In this study, we found that methyltrans…
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