Med (New York, N.Y.)HumansImmune Checkpoint InhibitorsReceptorsImmunologicNeoplasms
Beyond TIGIT: Lessons from a failed immune checkpoint for rational target discovery.
Jiatong Ding, Shuhang Wang, Ning Li
Published: 202510.1016/j.medj.2025.100937
Abstract
The clinical failure of TIGIT inhibitors resulted from an incomplete mechanistic understanding, lack of predictive biomarkers, and functional redundancy with PD-1. Future success requires a focus on PD-1-refractory tumors, improved humanized models,…
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