Med (New York, N.Y.)HumansIschemic StrokeThrombolytic TherapyFibrinolytic AgentsRandomized Controlled Trials as Topic
Thirty years of intravenous thrombolysis for acute ischemic stroke: Historical perspectives, evidence from randomized trials, and emerging directions.
Hugo Diaz, Samuel Mouyal, Mathieu Zuber, Claire Join-Lambert, Mikael Mazighi, Jean-Marc Olivot, Benjamin Maïer
Published: 202610.1016/j.medj.2025.100888
Abstract
Intravenous thrombolysis (IVT) remains a cornerstone in the management of acute ischemic stroke (AIS). Since the landmark NINDS and ECASS III trials, numerous randomized controlled trials (RCTs) have expanded IVT indications beyond the initial 4.5-h…
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