Molecular & cellular proteomics : MCP
Modanovo: A Unified Model for Post-translational Modification-Aware De Novo Sequencing Using Experimental Spectra From In Vivo and Synthetic Peptides.
Daniela Klaproth-Andrade, Yanik Bruns, Wassim Gabriel, Christian Nix, Valter Bergant, Andreas Pichlmair, Mathias Wilhelm, Julien Gagneur
Published: 202510.1016/j.mcpro.2025.101501
Abstract
Post-translational modifications (PTMs) play a central role in cellular regulation and are implicated in numerous diseases. Database searching remains the standard for identifying modified peptides from tandem mass spectra but is hindered by the comb…
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