MaturitasHumansFemaleEstradiolCase-Control StudiesFinland
Vaginal use of estradiol is associated with a reduced risk of rectal cancer in postmenopausal women: A Finnish nationwide case-control study.
Heli Siitonen, Johanna M Joensuu, Hanna Savolainen-Peltonen, Mika Gissler, Tomi S Mikkola, Olavi Ylikorkala
Published: 202610.1016/j.maturitas.2025.108802
Abstract
OBJECTIVE: We assessed the impact of vaginal estradiol on the risk of rectal cancer. STUDY DESIGN: We identified in this nationwide case-control study primary rectal cancer cases with five age-matched control cases in 1994-2019 from our dataset of 1.…
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