Molecular aspects of medicineHumansDiabetes MellitusType 2NeoplasmsCalcium Signaling
Membrane remodeling, ion channels, Ca2+ signaling, and stress pathways as molecular links between type 2 diabetes and cancer.
Gonzalo Ferreira, Luisina Chavarría, Agustín DeMarco, Franco Bernech, Romina Cardozo, Axel Santander, Lucía Domínguez, Nicolás Mujica, Luis Sobrevia, Garth L Nicolson
Published: 202510.1016/j.mam.2025.101426
Abstract
The interrelationship between type 2 diabetes mellitus (T2DM) and cancer reflects a convergence of molecular disturbances involving metabolism, inflammation, and cellular stress, often underpinned by genetic alterations. This review examines some key…
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