Molecular aspects of medicineHumansDepsipeptidesSARS-CoV-2Antiviral AgentsCOVID-19
Pharmacological reprogramming of plitidepsin as a SARS-CoV-2 inhibitor.
Jose Jimeno, Jose Felipe Varona, Jose A Lopez-Martin, Nuria Izquierdo-Useros, Elisa Molina Molina, Pablo Guisado-Vasco, Martin Sachse, Cristina Risco, Alejandro Losada, Salvador Fudio, Erik Luepke, Antonio Nieto, Javier Gomez, Pablo Aviles, Carmen Cuevas
Published: 202510.1016/j.mam.2025.101412
Abstract
Selective pressures in the ocean promote the evolution of potent molecules that may be useful in therapeutic settings. Tunicates provide a rich source of bioactive molecules that have been shown to have anti-neoplastic and anti-microbial activities.…
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