Mechanisms of ageing and development
SRC suppression attenuates vascular aging by activating FUNDC1-dependent mitophagy.
Linghuan Wang, Yan Ma, Tianhu Wang, Weiwei Zhang, Zhiyi Fang, Tingting Lu, Yingjie Zhang, Yan Fang, Ting Sun, Dong Han, Feng Cao
Published: 202610.1016/j.mad.2026.112156
Abstract
Vascular smooth muscle cell senescence contributes critically to vascular remodeling and atherosclerosis, with mitochondrial dysfunction and impaired mitophagy recognized as major contributors. SRC, a stress-responsive tyrosine kinase, has been linke…
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