Mechanisms of ageing and developmentHumansGrowth Differentiation Factor 15AgedMaleFemale
Circulating mitokines GDF-15 and FGF21 are associated with frailty, sarcopenia, and malnutrition in older adults: Evidence from the FRASNET study.
Sarah Damanti, Clara Sciorati, Rebecca De Lorenzo, Amanda Avola, Maria Pia Ruggiero, Simona Santoro, Eleonora Senini, Marco Messina, Francesca Farina, Costanza Festorazzi, Giulia Pata, Martina Laffranchi, Martina Mallus, Elena Brioni, Lorena Citterio
Published: 202510.1016/j.mad.2025.112124
Abstract
BACKGROUND: Mitochondria-derived GDF15 and FGF21, known as mitokines, are emerging biomarkers of metabolic stress and aging-related decline. Their roles in energy balance, inflammation, and muscle metabolism suggest potential for predicting geriatric…
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