Lung cancer (Amsterdam, Netherlands)HumansCarcinomaNon-Small-Cell LungLung NeoplasmsNeoadjuvant Therapy
Multiomic analysis of treatment-naïve NSCLC before the era of neoadjuvant immunotherapy reveals contrasting immune phenotypes in stage IIIA: node-dominant (T1N2) exhibiting hot versus tumor-dominant (T4N0) cold features.
Duk Ki Kim, Yooyoung Chong, Min-Kyung Yeo, Da Hyun Kang, Joo-Eun Lee, Hyun-Yi Kim, Min-Woong Kang, Chaeuk Chung
Published: 202610.1016/j.lungcan.2025.108879
Abstract
BACKGROUND: Non-small cell lung cancer (NSCLC) exhibits substantial heterogeneity in its tumor immune microenvironment, which critically influences therapeutic outcomes. Recently, immune checkpoint inhibitors (ICIs) have been increasingly incorporate…
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