Lung cancer (Amsterdam, Netherlands)HumansCarcinomaNon-Small-Cell LungLung NeoplasmsProto-Oncogene Proteins p21(ras)
KRASG12D/G13D-USP15 axis promotes TGF-β/SMAD signaling and glycolytic flux to accelerate NSCLC pathogenesis.
Ikhlas A Sindi, Abdelghafar M Abu-Elsaoud, Amany I Almars, Nahlah M Ghouth, Sameerah Shaheen, Ahmed M Basri, Zaki H Hakami, Tawfiq N Jurayb, Abdullah A Alqasem, Iman S Abumansour, Hind M Naffadi, Nasser A Elhawary, Hassan Rudayni, Mohammed Al-Zharani, Lina M Alneghery
Published: 202610.1016/j.lungcan.2025.108848
Abstract
BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related mortality worldwide, with activating KRAS mutations representing a key oncogenic driver. These mutations profoundly reprogram cellular metabolism, especiall…
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