Life sciencesAnimalsLactococcus lactisMiceInbred C57BLT-Lymphocytes
Lactococcus lactis expressing IL-6 supplementation promotes the Tr17 regulatory cell differentiation in the gut and alleviates the metabolic and inflammatory dysfunction in an experimental model of diet-induced type 2 diabetes.
Thaílla Cristina Faria Pacheco, Sara Cândida Barbosa, Jefferson Elias-Oliveira, Ítalo Sousa Pereira, Vanessa Fernandes Rodrigues, Melissa Santana Gonsalez Machado, Wendy Martin Rios, Anderson Dos Santos Ramos, Jéssica Assis Pereira, Raquel Pires Nakama, Rita Cássia Tostes, Luis Gilberto Bermudez-Humaran, Daniela Carlos
Published: 202610.1016/j.lfs.2025.124112
Abstract
Obesity and metabolic syndrome are linked to chronic inflammation and insulin resistance (IR) in adipose tissue (AT), contributing to type 2 diabetes (T2D). Regulatory T cells expressing RORγt and Foxp3 (Tr17 cells) have immunosuppressive functions,…
Preview only. Read the full abstract at the source