Life sciencesAnimalsSepsisMaleRatsWistar
Phosphodiesterase 3 inhibition mitigates sepsis progression in a rodent sepsis model.
Junior Garcia Oliveira, Gustavo Ferreira Alves, Elaine Leocádia Anton, Eduardo Souza-Silva, José Eduardo da Silva-Santos, Priscila Laiz Zimath, Gabrielle Delfrate, Marcelo Falchetti, Natã Machado, Martin Vojtek, Marcia Regina Paes Oliveira, Patrícia Dias-Pereira, Regina Sordi, Carmen Diniz, Daniel Fernandes
Published: 202510.1016/j.lfs.2025.124053
Abstract
BACKGROUND: Sepsis, a life-threatening organ dysfunction caused by a dysregulated host immune response to infection, disrupts intracellular messengers, such as cyclic nucleotides cAMP and cGMP, contributing to high mortality. AIMS: To investigate the…
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