Life sciencesAnimalsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsRewardRatsMale
Blockade of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels reduces alcohol-induced dopamine release and reward in rats.
Ignacio Gutiérrez-Vega, Isidora Schneider, Constanza Cáceres, Mario Herrera-Marschitz, María Novella Romanelli, Paola Morales, María Elena Quintanilla, David Vásquez, Mario Rivera-Meza
Published: 202510.1016/j.lfs.2025.124043
Abstract
The rewarding properties of alcohol (ethanol) play a central role in perpetuating dysfunctional consumption behaviors. Ethanol activates dopaminergic neurons in the ventral tegmental area (VTA), increasing dopamine release in the nucleus accumbens (N…
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