Life sciencesAnimalsGentamicinsNF-E2-Related Factor 2RatsMale
Nicardipine protects against gentamicin-induced nephrotoxicity: Potential involvement of IL-23R, NRF2, and Beclin-1 perturbation.
Marwa M N Ashour, Ahmed M Abd-Eldayem, Ehab A M El-Shoura, Basim A S Messiha, Souty M Z Sharkawi
Published: 202510.1016/j.lfs.2025.124042
Abstract
AIMS: Gentamicin (GNT) remains a cornerstone in the treatment of severe Gram-negative infections; however, its clinical utility is constrained by dose-limiting nephrotoxicity. Emerging evidence implicates nicardipine (NIC), a dihydropyridine calcium…
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