Life sciencesMaleAnimalsRatsEndoplasmic Reticulum StressTestis
Linking GLP-1 activation with steroidogenesis, redox, endoplasmic reticulum stress, mitophagy, and the apoptotic regulatory network unlocks the emerging impacts of semaglutide on 5-fluorouracil-induced testicular toxicity.
Noha F Hassan, Haneen Y Khidr, Rania Farag A Eltelbany, Mona M Abd El-Galil, Enji Reda, Nahla A El-Zohairy, Ayah M H Gowifel
Published: 202510.1016/j.lfs.2025.124014
Abstract
AIMS: One of the recent growing complications of neoplastic chemotherapy that is considered a challenge in their therapeutic protocol is testicular dysfunction. The pathogenesis of testicular injury is multifactorial, involving various pathogenic mec…
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