Life sciencesAnimalsMiceMacrophagesCell ProliferationTransforming Growth Factor beta1
Esaxerenone inhibits renal macrophage proliferation through MR/TGF-β1 pathway in db/db mice.
Fengwen Yang, Ziqian Liu, Yuan Li, Ruyan Lv, Yicong Zhao, Fan Yang, Tatsuo Shimosawa, Jinchuan Tan, Qingyou Xu, Panpan Qiang
Published: 202510.1016/j.lfs.2025.124008
Abstract
AIMS: To investigate the effect of mineralocorticoid receptor (MR) blockade esaxerenone on renal macrophage proliferation in db/db mice and its potential role in the progression of diabetic kidney disease (DKD). MATERIALS AND METHODS: Eight-week-old…
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