The Lancet. Microbe
Controlled human infection with Mycobacterium tuberculosis: practical considerations for clinical trials.
Chetan Seshadri, JoAnne L Flynn, Pauline Maiello, Dirk Schnappinger, Robert J Wilkinson, Stephen B Gordon, Henry C Mwandumba, Kondwani C Jambo, Daniel F Hoft, Eric J Rubin, Euzebiusz Jamrozik, Sarah M Fortune, James G Kublin
Published: 202610.1016/j.lanmic.2025.101278
Abstract
Controlled human infection models (CHIMs) can accelerate vaccine development for infectious diseases. Mycobacterium tuberculosis is a human-adapted pathogen that is the leading infectious cause of death worldwide. M tuberculosis infection results in…
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