Laboratory investigation; a journal of technical methods and pathology
Differential Expression of PIWI-interacting RNAs in Glioblastoma Stem Cells Affects Their Biological Features: Implications for Tumor Progression and Patient Survival.
Frantisek Siegl, Elena Garcia-Borja, Rosana Mateu, Karolina Trachtova, Matej Jasik, Martin Kopecky, Marek Vecera, Lenka Radova, Michal Hendrych, Tomas Kazda, Pavel Fadrus, Aleksi Sedo, Ondrej Slaby, Petr Busek, Jiri Sana
Published: 202610.1016/j.labinv.2026.106072
Abstract
Glioblastoma IDH-wild type (GBM) is the most lethal and, concurrently, the most common malignant primary brain tumor. Its aggressive behavior is associated with the presence of a subpopulation of glioblastoma stem cells (GSC) that drive resistance to…
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