Laboratory investigation; a journal of technical methods and pathology
Diagnostic Potential of Tn-MUC1 in Breast Cancer: A Novel Immunohistochemical Marker Reflecting Tumor Progression.
Ai Shimizu, Kanako C Hatanaka, Ayae Nange, Asami Okumura, Masanori Takehashi, Yoshiki Shinomiya, Kentaro Naruchi, Masaharu Sato, Hiroshi Kase, Tomoko Mitsuhashi, Hiroko Yamashita, Yutaka Hatanaka, Yoshihiro Matsuno
Published: 202610.1016/j.labinv.2025.106070
Abstract
Mucin 1 (MUC1) is a highly O-glycosylated transmembrane glycoprotein. Tumor-associated (TA) MUC1 (TA-MUC1), characterized by aberrant O-linked glycans, is overexpressed in cancer cells; however, conventional MUC1 antibodies show limited specificity f…
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