Laboratory investigation; a journal of technical methods and pathologyColorectal NeoplasmsGlycolysisHumansAnimalsTumor Microenvironment
Glycolysis Inhibition Restores Immune Sensitivity in GSNOR-Deficient Colorectal Cancer.
Ana Mantrana, María Teresa Sánchez-Montero, Carmen Navarrete-Sirvent, Nerea Herrera-Casanova, Rafael Mena-Osuna, Aurora Rivas-Crespo, Alejandra Díaz-Chacón, Virginia Ávila-Oca, Marta Toledano-Fonseca, María Victoria García-Ortíz, Rafael González-Fernández, María Auxiliadora Gómez-España, Carlos Villar, Francisco Javier Medina-Fernández, Enrique Aranda
Published: 202510.1016/j.labinv.2025.104250
Abstract
S-nitrosoglutathione reductase (GSNOR) is increasingly recognized as a tumor suppressor, and we have recently reported that its deficiency drives an aggressive and immune-evasive phenotype in colorectal cancer (CRC). However, the mechanisms linking G…
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