The Knee
Thrombospondin-4 correlates with MRI measures of structural damage and pain sensitisation: a new biomarker in knee osteoarthritis.
Franklyn Arron Howe, Soraya Koushesh, Anna Blundell, Amber Law, Abiola Harrison, Vivian Ejindu, Seyi Taylor-Kuti, Andisheh Niakan, Mary Sheppard, Richard Ljuhar, Nidhi Sofat
Published: 202510.1016/j.knee.2025.104305
Abstract
BACKGROUND: We hypothesised thrombospondin-4 (TSP-4), a molecule mediating pain sensitisation in peripheral nerve injury, is associated with pain sensitisation in OA. METHODS: A cross-sectional study of clinical, imaging and fluid biomarkers from kne…
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