Kidney international
Multi-omics analyses reveal the pathogenic role of terminal ileum-derived IgA+β7+ cells in IgA nephropathy.
Xingzi Liu, Lan Wang, Miaomiao Lin, Niya Jia, Guanyi Liu, Jiawen Peng, Jingyu Wang, Tong Xie, Shaoqing Dang, Jingyi Wu, Xujie Zhou, Lijun Liu, Sufang Shi, Jicheng Lv, Jonathan Barratt
Published: 202610.1016/j.kint.2025.12.026
Abstract
INTRODUCTION: Galactose-deficient IgA1 (Gd-IgA1) plays a key role in IgA nephropathy (IgAN), but the location of the plasma cells responsible for its production remain unknown. METHODS: To locate Gd-IgA1-producing cells, we profiled intestinal and ci…
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