Kidney internationalAnimalsGlomerulonephritisMembranousReceptorsPhospholipase A2
Patient anti-PLA2R1 autoantibodies cause membranous nephropathy in human PLA2R1 transgenic mice.
Gunther Zahner, Silke Dehde, Larissa Seifert, Ming Huang, Oliver Kretz, Tobias B Huber, Nicola M Tomas
Published: 202510.1016/j.kint.2025.08.026
Abstract
INTRODUCTION: The discovery of anti-phospholipase A2 receptor 1 (PLA2R1) autoantibodies in patients with membranous nephropathy (MN) has led to a paradigm change in diagnosis, monitoring, risk prediction, and therapy of this autoimmune disease. Howev…
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