Journal of virological methodsVaccinesAttenuatedHepatitis A VaccinesFreeze DryingReal-Time Polymerase Chain Reaction
Rapid establishment and validation of a PMAxx-RT-qPCR method for infectious titer detection of freeze-dried live attenuated hepatitis A vaccine (H2 Strain).
Yongrong Wang, You Gao, Wei Wang, Qin Liu, Yadong Li, Haiyuan Zeng, Lifei Chen, Chen Cheng, Fan Wu
Published: 202610.1016/j.jviromet.2025.115333
Abstract
The infectious titer of hepatitis A virus (HAV) is a critical quality parameter for evaluating potency of freeze-dried live attenuated hepatitis A (HepA-L-fd) vaccines. In this study, we developed a rapid PMAxx-RT-qPCR for detecting the infectious ti…
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