Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Clinical Significance of MTAP Deletions and Their Overlap With Concurrent Oncogenic Driver Alterations Including EGFR in NSCLC.
Jessica S Ross, Rohit Thummalapalli, Christopher A Febres-Aldana, Daniel Muldoon, Christina Falcon, Amanda Pupo, Noura J Choudhury, Guillherme Harada, Soo-Ryum Yang, Scott Eckert, Francis M Bodd, Jennifer L Sauter, Chaitanya Bandlamudi, Michael Berger, Mark Y Jeng
Published: 202510.1016/j.jtho.2025.11.010
Abstract
INTRODUCTION: Methylthioadenosine phosphorylase (MTAP) deletions (dels) occur with CDKN2A dels in a subset of NSCLCs. These deletions have been associated with inferior survival in several tumor types, and they may be targetable by PRMT5 and MAT2A in…
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