Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
GSTA1 Conferred Tolerance to Osimertinib and Provided Strategies to Overcome Drug-Tolerant Persister in EGFR-Mutant Lung Adenocarcinoma.
Xiaoshen Zhang, Yaokai Wen, Fengying Wu, Yu Jiang, Yuechun Lin, Lei Wang, Fei Zhou, Yue Shen, Zhen Min, Wei Li, Wenhua Liang, Jianxing He, Caicun Zhou
Published: 202510.1016/j.jtho.2025.10.001
Abstract
INTRODUCTION: The generation of drug-tolerant persister (DTP) cancer cells remains a major challenge in treating lung adenocarcinoma (LUAD) patients with EGFR tyrosine kinase inhibitors (TKIs), as these cells eventually drive drug resistance and dise…
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