Journal of thrombosis and haemostasis : JTH
Engineering a membrane-independent human prothrombinase through parsimonious mutation of factor Xa.
Fatma Işık Üstok, James A Huntington
Published: 202510.1016/j.jtha.2025.10.015
Abstract
BACKGROUND: Thrombin is generated from its precursor prothrombin by sequential cleavage at Arg320 and Arg271 by the prothrombinase complex, composed of factor (F)Xa and FVa on phospholipid (PL) surfaces. The affinity of human FXa for FVa is low in th…
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