Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
The toxic effect of Cu2+ on cultured astrocytes of the rat cerebral cortex is associated with the nucleolar stress.
Nickolay K Isaev, Elizaveta E Genrikhs, Elena A Smirnova, Wenzhu Wang, Alina E Lapieva, Sergey A Golyshev, Dmitry N Voronkov, Anna B Strizhkova, Arseniy K Berdnikov, Elena V Stelmashook
Published: 202610.1016/j.jtemb.2026.127821
Abstract
Copper-induced cell death (cuproptosis) is implicated in the pathogenesis of Wilson's disease, there-fore it is important to understand how copper ions can affect brain astrocytes, as these cells play an important role in copper metabolism. The cultu…
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