Transplantation and cellular therapy
Letermovir Prophylaxis Does Not Hinder Immune Reconstitution While Reshaping Viral Infection Landscape in Children.
Manuela Spadea, Francesca Romani, Silvia Nucera, Alessio Tomatis, Raffaele Vitale, Viola Carzaniga, Francesco Baccelli, Alessandro Di Gangi, Francesca Dagliano, Vincenzo Apolito, Valeria Ceolin, Francesca Gottardi, Francesco Saglio, Mariacristina Menconi, Riccardo Masetti
Published: 202510.1016/j.jtct.2025.12.995
Abstract
BACKGROUND: Letermovir prophylaxis in adults reduces CMV-related morbidity and mortality and may delay T-cell recovery. Pediatric data are limited. OBJECTIVES: We aimed to compare absolute counts of CD3⁺, CD3⁺CD4⁺, CD3⁺CD8⁺, CD19⁺, CD3-CD16⁺CD56⁺ cel…
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