Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Outcomes of low-dose versus standard-dose alteplase in acute ischemic stroke patients aged over 80 years: A real-world propensity score-matched study from China.
Chang-Sheng Li, Hong-Qiu Gu, Kai-Xuan Yang, Zi-Mo Chen, Xia Meng, Chun-Juan Wang, Zi-Xiao Li
Published: 202610.1016/j.jstrokecerebrovasdis.2026.108548
Abstract
BACKGROUND: Optimal alteplase dosing for intravenous thrombolysis in stroke patients aged >80 years remains debated due to underrepresentation in pivotal trials. This study evaluates the relative effectiveness and safety of low-dose (0.6 mg/kg) versu…
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