The Journal of steroid biochemistry and molecular biologyHumansPyroptosisDNA MethylationEstradiolBreast Neoplasms
17 β-Estradiol inhibits GSDME-mediated pyroptosis in ERα-positive breast cancer cells by promoting GSDME promoter methylation.
Yu Pan, Rui Li, Huanhuan Ma, Xiaolei Hu, Jun Zhao, Juanjuan Qiao, Xiyao Dou, Yanan Wang, Yanzhi Zhang, Xiuli Wang, Lin Wang
Published: 202610.1016/j.jsbmb.2025.106920
Abstract
Expression of the critical pyroptosis protein gasdermin E (GSDME) has been reported to be regulated by DNA methylation and negatively correlated with the expression of estrogen receptor (ER) in breast cancer tissues, suggesting that estrogen-induced…
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