Journal of structural biologyEscherichia coliCrystallographyX-RayAnti-Bacterial AgentsSerine Endopeptidases
Crystal structure of Escherichia coli type I signal peptidase P84A in complex with lipopeptide antibiotic arylomycin A2.
Chuanyun Luo, Mark Paetzel
Published: 202510.1016/j.jsb.2025.108260
Abstract
Type I signal peptidase (SPase I) is an essential membrane-bound enzyme that removes amino-terminal signal peptides from secretory proteins. Owing to its critical role in bacterial viability and its periplasmic accessibility, SPase I has emerged as a…
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