Journal of reproductive immunology
Comparison of IgG4 and asymmetric IgG and their similar properties as blocking antibodies.
Penghao Li, Yiqun Geng, Xiaomiao Yan, Weifeng Zhang, Sujuan Zhang, Jingliang Xu, Qu Zheng, Qiaoxiu Gu, Ziqi Zhu, Qiaoling Hu, Jiang Gu
Published: 202510.1016/j.jri.2025.104807
Abstract
BACKGROUND: Blocking antibody can inhibit immunoreactions. IgG4 and asymmetric (asym) IgG are both referred to as "blocking antibodies". However, their working mechanisms and effects on maternal-fetal immune tolerance in pregnancy remain unclear. MET…
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