Journal of psychiatric research
A novel, experimental design to assess rapid antidepressant action: Results from a phase 1b randomized trial of NV-5138.
Steven D Targum, Gerard Sanacora, Andrea E Formella, Gianpiera Ceresoli-Borroni, Randall Owen
Published: 202610.1016/j.jpsychires.2026.01.006
Abstract
BACKGROUND: Assessment of rapid-acting antidepressants (RAADs) requires rating scales sensitive to symptomatic changes over short time frames (hours to days). An innovative trial design was employed in an exploratory, first-in-human, phase 1b trial a…
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