Journal of psychiatric researchHumansAzepinesMajor Depressive DisorderOrexin Receptor AntagonistsSleep Initiation and Maintenance Disorders
Efficacy and safety profiles of FDA-approved dual orexin receptor antagonists in depression: A systematic review of pre-clinical and clinical studies.
Shreya Vasudeva, Sabrina Wong, Gia Han Le, Christine E Dri, Kayla M Teopiz, Roger Ho, Taeho Greg Rhee, Roger S McIntyre
Published: 202510.1016/j.jpsychires.2025.10.001
Abstract
BACKGROUND: Sleep disturbances, such as insomnia, are a group of prevalent and debilitating symptoms of Major Depressive Disorder (MDD). Dual Orexin Receptor Antagonists (DORAs) have emerged as potential treatments for insomnia and comorbid psychiatr…
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