Journal of psychiatric researchHumansMental DisordersClinical Trials as TopicTreatment OutcomeComputer Simulation
Estimating heterogeneity of treatment effect in psychiatric clinical trials.
Joshua S Siegel, Jinglin Zhong, Sasagu Tomioka, Ajay Ogirala, Stephen V Faraone, Steven T Szabo, Kenneth S Koblan, Seth C Hopkins
Published: 202510.1016/j.jpsychires.2025.09.070
Abstract
Currently, placebo-controlled clinical trials report mean change and effect sizes, which masks information about heterogeneity of treatment effects (HTE). Here, we present a novel method to estimate HTE and evaluate the null hypothesis (H0) that a dr…
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